The Coliprotec® vaccine line is stemming from research conducted by Dr. John M. Fairbrother, at the Reference Laboratory for Escherichia coli of the World Organisation for Animal Health (OIE), part of Université de Montréal’s Faculty of Veterinary Medicine.

These live vaccines immunize pigs against important diseases associated to the bacteria Escherichia coli. These single-dose vaccines can be administered in the pigs’ drinking water, which is a huge advantage from a logistical perspective. With this mode of administration, pigs no longer need to be handled individually, greatly reducing both labour costs and animal stress. Depending on the circumstances, Coliprotec® vaccines can also be administered individually using a dosing gun.

The Coliprotec® F4 is Prevtec Microbia’s flagship. Our vaccine provides an active immunization against post-weaning diarrhea (PWD) caused by enterotoxigenic Escherichia coli with attachment factor F4 (F4-ETEC). F4 is also known as K88.

The Coliprotec® F18 is the second product of Prevtec Microbia. It provides an active immunization against PWD caused by F18-positive enterotoxigenic E. coli (F18-ETEC) and edema disease (ED) caused by F18-positive shigatoxin-producing E. coli (F18-STEC).

The Coliprotec® F4/F18 is the most innovative product, with the broadest coverage, of the Coliprotec® line. This bivalent vaccine offers an active immunization against the two most common causes of PWD and ED.

Prevtec Microbia products mentioned on this site are not available in all countries. Indications may vary from one country to another. Please consult your veterinarian.


The PWD and ED are diseases related to various strains of Escherichia coli (E. coli) that pose a serious threat to the swine production industry. PWD and ED occur worldwide and are a common cause of mortality and significant growth delays in piglets.

E. coli is a diversify species of bacteria. The majority of E. coli are useful and part of the common bacteria flora of mammal intestines including swine. However, some strains of E. coli have virulence factors that can cause PWD and ED in piglets.


Once ingested, enterotoxigenic Escherichia coli with the attachment factor F4 (F4-ETEC) or F18 (F18-ETEC) bind to specific receptors of the pig’s intestinal cells. Once the intestine is colonized, the F4-ETEC and/or F18-ETEC release toxins that cause a loss of water and electrolytes in the pig’s intestine, leading to diarrhea, suppressed appetite, weight loss and in some cases death. From 20 to 50% of piglets can be affected and the mortality rate is usually between 2 and 5%. In addition, more than 20% of the piglets may die if the situation is not controlled. Mortality can be caused by dehydration but it can also be observed in piglets without clinical signs. Studies* of PWD-related mortality, growth delays and treatment costs have shown that the economic impact for producers ranges from USD $3.13 to USD $5.88 per pig, which is a significant portion of a pig’s value and has a considerable effect on a swine operation’s profitability.

* Tokach et al., 2000.


The ED is a very deadly disease which is seen in pig production worldwide. Usually ED occurs within the first weeks after weaning and in some cases in older animals. The morbidity (sick animal rate) varies from a production to another however the mortality is always high (>90%) for pigs with clinical signs (as convulsions, ataxia, anorexia, paralysis and lying on the side with or without paddling). The edema of the eyelids and face is not always observed. The disease is caused by a proliferation of Shigatoxin-producing E.coli with the attachment factor F18 (F18-STEC). The Shigatoxin is also known as Verotoxin.

THE COLIPROTEC® LINE: a sustainable solution

Antibiotic use has become a major concern for governments, health professionals and consumers. This is due to the observation of an increasing trend in the incidence of antibiotic resistance in certain bacterial populations in animals and humans, related to repeated use of antibiotics. Bacteria is said to be resistant when an antibiotic’s capacity to kill or limit its growth is compromised.

Legislative and regulatory measures have been applied in several countries to better regulate antibiotics in order to reduce or even prohibit their use in food animals.

In this context, the Coliprotec® vaccines represent a sustainable alternative for combatting PWD and ED in piglets.

Coliprotec® vaccines immunize pigs against the bacteria that cause PWD and ED, thus helping to reduce the use of the antibiotics traditionally administered to prevent and treat the disease.

They are also an alternative to zinc oxide, which is often used to prevent PWD. Zinc oxide is a heavy metal that threatens the environment and can promote antibiotic resistance in bacteria.

The strains of E. coli in Coliprotec® vaccines do not cause diseases, they immunize the pigs to which it is administered.

When the oral vaccine is administered, live E. coli bind to intestinal cells, multiply and trigger the animal’s immune response. The antibodies produced and henceforth present in the animal’s intestine prevent virulent E. coli from binding to the intestinal cells, thus preventing PWD and ED.

and development

Prevtec Microbia’s innovation strategy is based on a program of partnerships with research labs that develop solutions to improve animal health and animal production performance, as well as food safety for humans.

We are constantly on the lookout for new discoveries to develop and commercialize in partnership, and therefore foster a direct link to a growing network of research and technology transfer institutions in the animal health industry.

Prevtec Microbia products mentioned on this site are not available in all countries. Indications may vary from one country to another. Please consult your veterinarian.